Glioblastoma Multiforme

Glioblastoma Multiforme

Glioblastoma is a quick-developing and critical brain tumor also known as a grade IV astrocytoma. It penetrates surrounding brain tissue but does not usually spread to other organs.

Glioblastoma, commonly known as glioblastoma multiforme, is a cancer that is difficult to treat and sometimes cures. However, treatments may help to limit the growth of cancer and alleviate symptoms.

What causes Glioblastoma Multiforme?

Glioblastoma cells have more genetic defects than other astrocytoma brain cancer cells. As a result, scientists believe that various congenital abnormalities have a role in developing these tumors. In addition, these genetic mutations can be caused by a variety of factors, including:

  • Inherited DNA defects
  • Collective effects of exposure to chemicals and other carcinogens
  • High-dose ionizing radiation exposure
  • Additional triggers (Not found yet)


Symptoms differ depending on the position of the tumor but may include any of the following:

  • Persistent headaches
  • Double or blurred vision
  • Vomiting
  • Loss of appetite
  • Changes in mood and personality
  • Inability to think and learn
  • New onset of seizures
  • Speech difficulty

Tests used to diagnose Glioblastoma Multiforme include:

  • Neurological examination
  • Imaging tests
  • Biopsy

Treatments include surgery, supported by daily radiation and oral chemotherapy for six-plus weeks. Then a six-month course of oral chemotherapy given five days a month is the standard of care for a Glioblastoma Multiforme. To start with, the neurosurgeon will remove as much of the tumor as possible, then medicated wafers may be implanted directly into the brain.